We use Pharmaceutical Grade, 99% Pure micron sized particle Trans-Resveratrol Extract with BioPerine® for Superior Performance. (All-natural purified polygonum cuspidatum root extract)
How does Resveratrol help with NAD+? Resveratrol is the most powerful naturally occurring compound that can directly turn on our longevity-genes called SIRTUINS. SIRTUINS are the NAD+ dependent longevity-genes, that when activated, for example by caloric-restriction, has been shown to extend lifespan in many animal models. Resveratrol also has many health promoting attributes, with a steady stream of research articles adding to its positive benefits on a regular basis. However, what makes Resveratrol specifically important to NAD+, is its ability to directly stimulate by allosteric modification, the bottleneck enzyme NMNAT. NMNAT is responsible for the biosynthesis and recycling of NAD+ in our bodies. Resveratrol speeds up the activity NMNAT, while also helping to suppress the cytokine-induced expression of CD38 (CD38 is the largest destroyer of the NAD+ molecule in our bodies). There is also evidence that Resveratrol can induce AMPK activation, improve NAMPT expression, inhibit mTOR and jumpstart old human senescent cells.
This makes Resveratrol a powerful and key nutrient that has a positive effect on all the currently known longevity pathways, SIRTUINS, mTOR and AMPK. One weakness with Resveratrol is poor bioavailability, meaning, most of it gets eliminated by the liver before it gets into the bloodstream, this can be corrected by adding BioPerine®, which we include in our formulation for superior absorption.
(click here to learn more about Trans-Resveratrol..)