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Energy | Anti-Aging | Antioxidants
In 2013, a team of Harvard researchers successfully showed for the first time, that aspects of the aging process may be reversible. They treated old mice with NMN - NICOTINAMIDE MONONUCLEOTIDE, a powerful and direct NAD+ precursor supplement. Remarkably, after only 10 days of treatment, key biological markers used to measure the aging process, resembled those of much younger mice. It was the human equivalent of a 60-year old with some biomarkers reversed, to resemble those of a 20-year old. See the article "A New—and Reversible—Cause of Aging" - Harvard Medicine School.
Joe Rogan talks NMN, Resveratrol and Longevity with Dr. David Sinclair - Very Educational Excellent Video!
The most powerful and direct NAD+ Precursor supplement. NMN is the actual compound used by Harvard scientists to reverse aspects of aging in old mice that ignited excitement in NAD+ Anti-Aging research.
A 12- month long study designed to evaluate the long-term effects of oral supplementation of NMN in mice, was remarkable! NMN supplemented mice vs a control group demonstrated significant differences in age-related body weight, energy metabolism, blood sugar, lipid metabolism, gene expression changes, mitochondrial function, eye function, bone density and immune function with no apparent toxicity. (The study was carried out by the University of Washington School of Medicine in St Louis.)
NADH is Nicotinamide Adenine Dinucleotide (NAD) + Hydrogen or reduced NAD.
NADH + CoQ10 is a versatile super-nutrient combination that uniquely promotes cellular energy by donating high-energy electrons to the body that creates ATP. It is particularly helpful with fatigue, low-energy, mental focus, stamina and exercise-endurance. Studies also show that the NADH + CoQ10 combination is a potent antioxidant against lipid-peroxidation. NADH that is successfully absorbed or transported into cells, is directly cycled into NAD+ by dehydrogenase enzymes such as LDH, MDH and GPDH. NADH + CoQ10 is a great addition to any serious NAD+ anti-aging regimen!
We use Pharmaceutical Grade, 99% Pure micron sized particle Trans-Resveratrol Extract with BioPerine® for Superior Performance. (All-natural purified polygonum cuspidatum root extract)
How does Resveratrol help with NAD+? Resveratrol is the most powerful naturally occurring compound that can directly turn on our longevity-genes called SIRTUINS. SIRTUINS are the NAD+ dependent longevity-genes, that when activated, for example by caloric-restriction, has been shown to extend lifespan in many animal models. Resveratrol also has many health promoting attributes, with a steady stream of research articles adding to its positive benefits on a regular basis. However, what makes Resveratrol specifically important to NAD+, is its ability to directly stimulate by allosteric modification, the bottleneck enzyme NMNAT. NMNAT is responsible for the biosynthesis and recycling of NAD+ in our bodies. Resveratrol speeds up the activity NMNAT, while also helping to suppress the cytokine-induced expression of CD38 (CD38 is the largest destroyer of the NAD+ molecule in our bodies). There is also evidence that Resveratrol can induce AMPK activation, improve NAMPT expression, inhibit mTOR and jumpstart old human senescent cells.
This makes Resveratrol a powerful and key nutrient that has a positive effect on all the currently known longevity pathways, SIRTUINS, mTOR and AMPK. One weakness with Resveratrol is poor bioavailability, meaning, much of it gets eliminated by the liver before it even gets into the bloodstream, this can be corrected by adding BioPerine®, which we include in our formulation for superior performance, up to 4x better.
(click here to learn more about Trans-Resveratrol..)
