We use Pharmaceutical Grade, 99% Pure micron sized particle Trans-Resveratrol Extract with BioPerine® for Superior Performance. (All-natural purified polygonum cuspidatum root)
How does Resveratrol help with NAD+? Resveratrol is the most powerful naturally occurring compound that can directly turn on our longevity-genes called SIRTUINS. SIRTUINS are the NAD+ dependent longevity-genes, that when activated, for example by caloric-restriction, has been shown to extend lifespan in many animal models. Resveratrol also has many health promoting attributes, with a steady stream of research articles adding to its positive benefits on a regular basis. However, what makes Resveratrol specifically important to NAD+, is its ability to directly stimulate by allosteric modification, the bottleneck enzyme NMNAT. NMNAT is responsible for the biosynthesis and recycling of NAD+ in our bodies. Resveratrol speeds up the activity NMNAT, while also helping to suppress the cytokine-induced expression of CD38 (CD38 is the largest destroyer of the NAD+ molecule in our bodies). There is also evidence that Resveratrol can induce AMPK activation, improve NAMPT expression and jumpstart old human senescent cells. This makes Resveratrol a powerful and key nutrient that can both activate our longevity-genes (SIRTUINS) and independently help support the baseline NAD+ pool. One weakness with Resveratrol is poor bioavailability, meaning, most of it gets eliminated by the liver, this can be corrected by adding BioPerine®, which we include in our formulation for superior absorption.
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