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In 2013, a team of Harvard researchers successfully showed for the first time, that aspects of the aging process may be reversible. They treated old mice with NMN - NICOTINAMIDE MONONUCLEOTIDE, a powerful and direct NAD+ precursor supplement. Remarkably, after only 10 days of treatment, key biological markers used to measure the aging process, resembled those of much younger mice. It was the human equivalent of a 60-year old with some biomarkers reversed, to resemble those of a 20-year old. See the article "A New—and Reversible—Cause of Aging" - Harvard Medicine School.
NEW NMN Transporter discovered (Slc12a8), NMN enters cells directly - Jan 7, 2019.
Washington University scientists find an unknown route for cellular fuel delivery
"Rewinding the Clock" March 22, 2018."
"Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds"
As we age NAD+ levels fall, within our cells the NAD pool helps to breakdown foods like sugar into ENERGY. NAD+ is extremely vital, primarily, because it is an absolute requirement for the function of our "longevity-genes" called SIRTUINS. SIRTUINS control gene-expression, they are responsible for regulating the state of other genes in our bodies, making sure that only the right ones are either turned on or off like switches. This keep cells working normally and healthy as the DNA code intended. However, NAD+ declines with age, causing reduced SIRTUIN activity, lower energy output and less physical stamina & endurance. Why? Because NAD+ gets used and CONSUMED as a substrate, for immune function response by ectoenzyme CD38, SIRTUIN gene silencing and for the repair of broken DNA strands. (learn more on the science page...)
It is now becoming evident and common knowledge that supporting the NAD pool is indispensable for promoting good health & wellness, especially as we age. The mounting evidence suggests that NMN is perhaps the most versatile and prolific NAD+ precursor supplement. Even though Nicotinamide Riboside (NR) is very popular, mainly because it was first to market. What is being sold is actually Nicotinamide Riboside Chloride (NR-Cl), a chemical compound that is a salt of Nicotinamide Riboside, because naturally occurring Nicotinamide Riboside cannot remain stable outside of the body. NMN on the other hand, is a completely natural compound that delivers NMN directly to cells, doing so via the newly discovered NMN transporter slc12a8. NMN is rapidly absorbed by the small intestine within 2-3 minutes, creating NAD+ in tissue by 10-30 minutes (mouse study). Do not be bamboozled by the heavy marketing, make sure you choose the all-natural Nicotinamide MONONUCLEOTIDE! One of the world's most renowned anti-aging scientist who is currently leading the charge, takes NMN and Resveratrol.
At MAAC10 (Mitochondrial Anti-Aging Coenzymes), our formulations work synergistically to help support and maintain the NAD pool, boost physical endurance & ATP- Energy levels, while working to suppress excessive free-radical formation. We believe that a comprehensive strategy offers a greater opportunity to achieve the best results.
NADH is Nicotinamide Adenine Dinucleotide (NAD) + Hydrogen or reduced NAD.
NADH + CoQ10 is a versatile super-nutrient combination that uniquely promotes cellular energy by donating high-energy electrons to the body that creates ATP. It is particularly helpful with fatigue, low-energy, mental focus, stamina and exercise endurance. Studies also show that the NADH + CoQ10 combination is a potent antioxidant against lipid-peroxidation. NADH that is successfully absorbed or transported into cells, is directly cycled into NAD+ by dehydrogenase enzymes such as LDH, MDH and GPDH. NADH + CoQ10 is a great addition to any serious NAD+ anti-aging regimen!
The most powerful and direct NAD+ Precursor supplement. NMN is the actual compound used by Harvard scientists to reverse aspects of aging in old mice that ignited excitement in NAD metabolomics.
A 12- month long study designed to evaluate the long-term effects of oral supplementation of NMN in mice, was remarkable!
NMN supplemented mice vs a control group demonstrated significant differences in age-related body weight, energy metabolism, blood sugar, lipid metabolism, gene expression changes, mitochondrial function, eye function, bone density and immune function with no apparent toxicity.
Very High Potency Formula, Purified Micronized Trans-Resveratrol Extract with BioPerine® for Superior Performance.
How does Resveratrol help with NAD+? Resveratrol is the most powerful naturally occurring compound that can directly turn on our longevity-genes called SIRTUINS. SIRTUINS are the NAD+ dependent longevity-genes, that when activated, for example by caloric-restriction, has been shown to extend lifespan in many animal models. Resveratrol also has many health promoting attributes, with a steady stream of research articles adding to its positive benefits on a regular basis. However, what makes Resveratrol specifically important to NAD+, is its ability to directly stimulate by allosteric modification, the bottleneck enzyme NMNAT. NMNAT is responsible for the biosynthesis and recycling of NAD+ in our bodies. Resveratrol speeds up the activity NMNAT, while also helping to suppress the cytokine-induced expression of CD38 (CD38 is the largest destroyer of the NAD+ molecule in our bodies). There is also evidence that Resveratrol can induce AMPK activation, improve NAMPT expression and jumpstart old human senescent cells. This makes Resveratrol a powerful and key nutrient that can both activate our longevity-genes (SIRTUINS) and independently help support the baseline NAD+ pool. One weakness with Resveratrol is poor bioavailability, meaning, most of it gets eliminated by the liver before it gets into the bloodstream. This is easily corrected by adding BioPerine® which we include in our micronized formulation for superior absorption.
(click here to learn more about Trans-Resveratrol..)
