NMN Nicotinamide Mononucleotide - $22.99
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NMN is the most efficient and effective way to boost NAD+ levels. When cells are low in NAD, they respond by turning on transporters to up-take NMN from the blood-stream.
NMN vs NR
Newly discovered NMN transporter gene SLC12A8 shows NMN enters cells directly putting an end to the assertion that NMN must turn into NR before entering cells. In fact, NMN has a rapid transport system that is specific to NMN, one that does NOT transport NR. It is now fair to say NMN is the most powerful NAD supplement and is superior to NR. The study found that when cells are low in NAD, they respond by expressing the SLC12A8 transporter gene, allowing for the efficient absorption of NMN from the bloodstream. The SLC12A8 transporter gene is found expressed in many tissues and is abundant in the gut, where NMN is rapidly absorbed from the small intestine within 2-3 minutes, turning into NAD+ in 10-30 min (mice study).
Sublingual NMN vs Capsules
The discovery of slc12a8 also puts an end to the notion that sublingual NMN is necessary, because we now know that the stomach can uptake NMN directly, the small intestine and even the colon have expression of the NMN transporter gene. Contrary to the claims that capsules get digested, almost no NMN is expected to go to waste, as the gut has an extremely high concentration of NMN transporters. It is also noteworthy, that some sublingual users have reported irritated gums and mouth sores.
NMN is utilized rapidly
The absorption and utilization of NMN happen very quickly, any testing methodology that waits for hours to test the effectiveness of NMN, will be or would have been inaccurate as was done in many of the prior studies. Testing the effectiveness of NMN must be done in real-time.
Slc12a8 is a nicotinamide mononucleotide transporter Jan 7, 2019 nature metabolism.
Natural compound reduces signs of aging in healthy mice - Washington University School of Medicine
Scientists unveil a giant leap for anti-aging - ScienceDaily
As we age, NAD+ levels fall. In simple terms, this is the core concept that is behind the science, a clear link between falling NAD levels and aging. This rate of decline is greater than the body’s own natural ability to replenish the supply. NMN Nicotinamide Mononucleotide is a direct NAD+ precursor supplement that helps to replenish the NAD+ supply. It has been established in principle, by treating old mice with NMN, that at least some biometric markers used to measure the aging process can be reversed.
Why is NAD+ so critical?
There are three fundamental functions that require NAD+ which are critical for the normal operation of all living cells. First, NAD+ is responsible for the production of ATP, the chemical energy necessary to sustain life. For example, turning food into energy requires the NAD+/NADH redox cycle cycle which drives mitochondrial oxidative phosphorylation. Secondly, SIRTUINS, the so-called "longevity-genes" that regulate or silence other genes, do not work without NAD+. Thirdly, NAD+ is a facilitator and a substrate that is used for the repair of broken DNA strands. This maintains the integrity of the genetic code by protecting against various mutations.
What causes NAD+ levels to fall?
NAD levels decline over time because NAD+ is used and CONSUMED as a substrate by SIRTUINS, DNA-Repair enzymes and aggressively by another enzyme called CD38 for calcium balancing and immune function response. Inflammatory cytokines released by the immune system causes the production of CD38. The problem is further exacerbated, at least in theory by senescent cells, cells that can no longer divide but increasingly causes the release of even more inflammatory cytokines and more CD38 expression. Eventually, more NAD gets consumed than the ability to replenish the supply, leading to the over-all decline that is experienced with aging.
It is now evident that supporting the NAD pool is vital for promoting good health & wellness, especially as we age. Take Action - Try NMN today!
Reference linkslearn more on the science page
"NMN is absorbed from the gut into blood circulation within 2–3 min and transported into tissues within 10–30 min (refs 5,15). NMN is then immediately utilized for NAD+biosynthesis, significantly increasing NAD+ content in tissues over 60 min"
The elusive NMN transporter is found - Jan 7, 2019
TIME-Mar 22, 2018
Old mice are new again: anti-ageing pill restores vitality
The Sydney Morning Herald-Mar 22, 2018
9news.com.au-Mar 23, 2018